Senolytics restore longevity proteins? (Alpha-Klotho)

Orally-active, clinically-translatable senolytics restore a-klotho in mice and humans. There you go that is the video. Boom. I’m joking, let’s take a look at this paper in more detail.

Klotho proteins are proteins found at the cell membrane . The gene encoding the protein was first uncovered in a mouse stain that displayed a complex aging phenotype suspected to be caused by a genetic alteration disrupting a putative “aging-suppressor” gene – because Klotho is the name of one of the goddesses of destiny in Greek mythology who spins the thread of life, the name was co-opted for the gene.

Whilst klotho goes down with aging, something else increases – the presence of senescent cells. But is this just correlation or causation?

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TIMESTAMPS:
Intro – 00:00
Klotho proteins – 00:30
Speedy senescent recap – 03:00
Klotho proteins and senolytics – 03:45

References:
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans – https://doi.org/10.1016/j.ebiom.2022.103912

Please note that The Sheekey Science Show is distinct from Eleanor Sheekey’s teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.

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