Hybridtides® are synthetic peptides based on the seminal work by Prof. Samuel Gellman at the University of Wisconsin. Hybridtides® provide a unique peptidomimetic scaffold that is both digestively and structurally stable. This stability arises from the proper incorporation of α and β amino acids, a process in which we are experts. A variety of peptide engineering opportunities are derivative from this fundamental scaffold.

Building on the Hybridtide® scaffold, Longevity Biotech has created a streamlined, high throughput, data-driven process to deliver peptides orally. Once the requisite digestive stability via the Hybridtide® Optimization Toolkit (HOT®) Hybridtides ® are evaluated and optimized for absorption via the Oral Peptide Platform (OPP). Finally, the resulting lead candidate is evaluated in vivo for absolute bioavailability.

To date, Longevity Biotech has applied the Hybridtide® scaffold primarily to the class B-GPCR family of drug targets – with great success. Currently, our Hybridtide® based neuroscience and diabetes programs target receptors in this family. These assets are in preclinical development along with several other projects as well. If there is any interest in learning more about these programs please contact us to learn more