DAVID SINCLAIR “Hormesis Activates Longevity Pathways” | Dr David Sinclair Interview Clips
According Dr David Sinclair, Hormesis is essentially what doesn’t kill you makes you stronger. What that means is anything that puts the body in a state of perceived adversity. You don’t want to actually damage the body to be able to live longer and be healthy. You want to give the impression that times are going to be tough. So being hungry during the day, exercising, these are all things that tell the longevity genes to come on and to protect the body. A stressed plant gives more polyphenols, eating stressed plants is one of the way to trigger longevity pathways as well.
David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.
Dr Sinclair has suggested that aging is a disease—and that we may soon have the tools to put it into remission—and he has called for greater international attention to the social, economic and political and benefits of a world in which billions of people can live much longer and much healthier lives.
Dr Sinclair is the co-founder of several biotechnology companies (Life Biosciences, Sirtris, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others.
He is also co-founder and co-chief editor of the journal Aging. He is an inventor on 35 patents and has received more than 35 awards and honors. In 2014, he was on Time Magazine’s list of the “100 Most Influential People in the World,” and listed as Time’s Top 50 in healthcare in 2018.
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